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| Diagnostic | Hepatocellular Carcinoma, Malignant Liver Neoplasm, Fibrolamellar Carcinoma, Hepatoblastoma | Statut d'étude | Open |
| Phase | II/III |
| Age | Enfant, Adulte (jusqu'à 30 ans) | Randomisation | YES |
| Ligne de traitement | First line treatment |
| Routes of Treatment Administration | Cisplatin: IV, Other drugs are given as usually administered for hepatoblastoma/liver cancer therapy |
| Last Posted Update | 2025-02-20 |
| ClinicalTrials.gov # | NCT03533582 |
International Sponsor
Children's Oncology GroupPrincipal Investigators for Canadian Sites
Alberta Children's Hospital - Dr. Victor A. Lewis
University of Alberta Hospital (Not Affiliated with U-Link) - Dr. Sarah J. McKillop
CancerCare Manitoba - Dr. Ashley Chopek
IWK Health Centre - Dr. Craig Erker
Hamilton Health Sciences Centre, McMaster University - Dr. Uma H. Athale
Cancer Centre of Southeastern Ontario at Kingston General Hospital - Dr. Laura Wheaton
Children's Hospital of Western Ontario - Dr. Shayna M. Zelcer
The Hospital for Sick Children - Dr. Furqan Shaikh
Montreal Children's Hospital - Dr. Sharon B. Abish
CHU Ste-Justine - Dr. Yvan Samson
CHU de Quebec - Dr. Bruno MichonCentres
Medical contact
Dr. Victor Lewis
Social worker/patient navigator contact
Wendy Pelletier
Clinical research contact
Debra Rich
Medical contact
Dr. Magimairajan Vanan
Social worker/patient navigator contact
Rhéanne Bisson
Clinical research contact
Rebekah Hiebert
Megan Ridler
Kathy Hjalmarsson
Medical contact
Dr. Craig Erker
Dr. Conrad Fernandez
Dr. Ketan Kulkarni
Social worker/patient navigator contact
Rhonda Brophy
Clinical research contact
Tina Bocking
Medical contact
Dr. Carol Portwine
Social worker/patient navigator contact
Jane Cassano
Clinical research contact
Sabrina Millson
Medical contact
Dr. Laura Wheaton
Dr. Mariana Silva
Social worker/patient navigator contact
Jessica Amey
Clinical research contact
Heather McLean
Medical contact
Dr. Alexandra Zorzi
Dr. Shayna Zelcer
Social worker/patient navigator contact
Cindy Milne Wren
Jessica Mackenzie Harris
Clinical research contact
Mariam Mikhail
Medical contact
Clinical Research Unit
Social worker/patient navigator contact
Clinical Research Unit
Clinical research contact
Stephanie Badour
Medical contact
Dr. Henrique Bittencourt
Dr. Monia Marzouki
Dr. Sebastien Perreault (neuro-onc)
Social worker/patient navigator contact
Marie-Claude Charrette
Clinical research contact
Marie Saint-Jacques
Medical contact
Raoul Santiago
Social worker/patient navigator contact
Isabelle Audet
Clinical research contact
Barbara Desbiens
Study Description
Cet essai étudie l'efficacité du cisplatine et de la chimiothérapie combinée dans le traitement des enfants et des jeunes adultes atteints d'hépatoblastome ou de cancer du foie après une intervention chirurgicale. Les médicaments utilisés en chimiothérapie, tels que le cisplatine, la doxorubicine, le fluorouracile, le sulfate de vincristine, le carboplatine, l'étoposide, l'irinotécan, le sorafénib, la gemcitabine et l'oxaliplatine, agissent de différentes manières pour arrêter la croissance des cellules tumorales, soit en tuant les cellules, soit en les empêchant de en les divisant ou en les empêchant de se propager. L'administration d'une chimiothérapie combinée après une intervention chirurgicale peut tuer davantage de cellules tumorales.
Inclusion Criteria
