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Title
Status

 

NMTRC014 - NMTT- Neuroblastoma Maintenance Therapy Trial Using Difluoromethylornithine (DFMO)

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NMTRC014 - NMTT- Neuroblastoma Maintenance Therapy Trial Using Difluoromethylornithine (DFMO)

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DiagnosisNeuroblastomaStudy StatusOpen
PhaseII
AgeChild, Adult - (1 Year to 30 Years )RandomisationNO
Line of treatmentFirst line treatment, Disease relapse or progression
Routes of Treatment AdministrationDFMO - oral Other drugs are given as usually administered for neuroblastoma therapy.
Last Posted Update2024-03-19
ClinicalTrials.gov #NCT02679144
International Sponsor
Giselle Sholler
Principal Investigators for Canadian Sites
CHU Ste-Justine - Dr. Pierre Tiera
CHU de Quebec - Dr. Bruno Michon
CHU Sherbrooke - Dr. Josée Brossard
Montreal Children's Hospital – Dr. Sharon Abish
Alberta Children's Hospital – Dr. Melanie Finkbeiner
CancerCare Manitoba – Dr. Ashley Chopek
Janeway Hospital - Dr. Paul Moorehead
Centres
Medical contact
Dr. Victor Lewis

 

Social worker/patient navigator contact
Wendy Pelletier
Clinical research contact
Debra Rich
Medical contact
Clinical Research Unit
 
Social worker/patient navigator contact
Clinical Research Unit
 
Clinical research contact
Stephanie Badour
 
Medical contact
Dr. Henrique Bittencourt
Dr. Monia Marzouki
Dr. Sebastien Perreault (neuro-onc)
 
Social worker/patient navigator contact
Marie-Claude Charrette
 
Clinical research contact
Marie Saint-Jacques
 
Medical contact
Raoul Santiago
 
Social worker/patient navigator contact
Isabelle Audet
 
Clinical research contact
Barbara Desbiens
 

 

Medical contact
Dr. Magimairajan Vanan
Social worker/patient navigator contact
Rhéanne Bisson
 
Clinical research contact
Rebekah Hiebert
Megan Ridler
Kathy Hjalmarsson

 

 

Medical contact
Dr. Paul Moorehead
 
Social worker/patient navigator contact
Stephanie Eason
 
Clinical research contact
Bev Mitchell
 
Medical contact
Dr. Josee Brossard 
Social worker/patient navigator contact
Please Contact Site Directly
 
Clinical research contact
Please Contact Site Directly 
 

 

 

Study Description

This study uses a drug called Difluoromethylornithine (DFMO) for patients with neuroblastoma in remission to assess the effectiveness of preventing recurrence. The study also looks at the side effects associated with these medication. DFMO is a medication taken by mouth. It is an blocker of ornithine decarboxylase, an enzyme involved with polyamine biosynthesis in the cancer cells, including neuroblastoma cells. 

Inclusion Criteria
  • Patients less than 30 years of age, with high-risk neuroblastoma in complete remission.