Canadian clinical trial registry

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Study Description

This is a phase 3 study for patients with newly diagnosed diffuse glioma. To be eligible for this study, the participant's cancer must have a mutation called H3 K27M. This study explores whether adding treatment with the experimental drug called ONC201 after radiotherapy is effective in patients with this type of cancer. 

Inclusion Criteria

• Able to understand the study procedures and agree to participate in the study by providing written informed consent and assent when applicable.
• Body weight ≥ 10 kg
• A new diagnosis of diffuse glioma with a H3 K27M mutation 
• Received frontline radiotherapy (radiation) within 2-6 weeks of starting this study
• Patient must be capable of self-care but may be unable to engage in normal activities or perform active work

Other inclusion and exclusion criteria may apply and will be discussed with you by the study team.

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Study Description

This is a phase I/II trial that studies how well the treatments tiragolumab and atezolizumab work when given to children with tumours that have either come back (relapsed) or did not respond to therapy (refractory). These tumours must have a certain mutation, meaning the cancer cells are missing important genes called SMARCB1 and SMARCA4. Tiragolumab and atezolizumab may help the body's immune system attack the cancer, and may interfere with the ability of tumor cells to grow and spread.

Inclusion Criteria

• Participants must be between 1-18 years old for part A of this study. There is no upper age limit for part B
• Participants must have one of the following cancers, that has either come back (relapsed) or did not respond to previous treatment (refractory):
  • Renal medullary carcinoma
  • Malignant rhabdoid tumor (extra-CNS)
  • Atypical teratoid rhabdoid tumor (CNS)
  • Poorly differentiated chordoma
  • Epithelioid sarcoma
• Cancer must have the eligible mutation (SMARCB1 or SMARCA4)
• Participants must be up and about for at least half their waking hours
• Participants must meet all bloodwork criteria outlined for this study

Other inclusion and exclusion criteria may apply and will be discussed with you by your clinical team

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Study Description

For patients who have medulloblastoma or ependymoma, there is a clear need to develop more effective therapies. This research will study an investigational drug called 131I-omburtamab, which is given in an intraventricular access device, to see if it is safe for children when added to standard chemotherapy (anti-cancer therapy). The research will also investigate whether the addition of 131I-Omburtamab lowers the chance of tumor growth and improves survival compared to patients in the past who only received chemotherapy and/or radiation therapy.

(via: PBTC-058 Patient and Family Summary_v2_05-28-2021.pdf)

Inclusion Criteria

Inclusion Criteria Group 1:

• Patients must have a confirmed diagnosis of medulloblastoma that has come back, progressed or not responded to other standard treatment
• Patients must be 21 years old or younger to participate 
• Patients must be willing to undergo a surgical procedure to place an appropriate intraventricular access device (e.g., programmable ventriculoperitoneal [VP] shunt or reservoir) if they do not have one already
• Patients must be able to be up and about for over half of their waking hours
• Organ function and blood work requirements must be met
• Patients must not be pregnant or get pregnant during the course of this study or for at least 6 months after. If patients are of childbearing or child fathering potential, they must be willing to use a medically acceptable form of birth control, including abstinence. 
• Patients receiving corticosteroids at a stable or decreasing dose for at least 7 days prior to enrollment are eligible
• Patients must be willing to agree with study visit requirements and be able to understand and sign a written informed consent document 

Inclusion Criteria Group 2: 

• Patients must have a confirmed diagnosis of ependymoma that has come back, progressed or not responded to other standard treatment
• Patients must have evidence of tumor reactivity for B7H3 (CD276), if prior testing is not available, patient samples must be sent to Memorial Sloan Kettering Cancer Center to be tested
• Patients must be 21 years old or younger to participate
• Patients must be willing to agree with study visit requirements and be able to understand and sign a written informed consent document 
• Patients screened for this trial should be expected to meet criteria for treatment as outlined in the protocol. 

Other inclusion criteria may apply and will be discussed with you by the study team.  

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Study Description

Testing the Combination of Two Immunotherapy Drugs (Nivolumab and Ipilimumab) in Children, Adolescent, and Young Adult Patients With Relapsed/Refractory Cancers That Have an Increased Number of Genetic Changes, The 3CI Study

This study investigates the side effects of the combination of two immunotherapy medications called nivolumab and ipilimumab, and to see how well they work in treating children, adolescents and young adults with cancers that have come back (relapsed) or does not respond to treatment (refractory) and have an increased number of genetic changes. Immunotherapy with nivolumab and ipilimumab may help the body's immune system attack the cancer, and may interfere with the ability of tumor cells to grow and spread.

This study is being done to help doctors learn if the combination of nivolumab and ipilimumab can help children, adolescents, and young adults patients live longer.

This study will have two parts

• PART I: A tissue sample from the tumour is analysed for "tumour mutation burden" level. Patients with elevated level may be eligible for Part II.
• PART II: Patients receive receive treatment with nivolumab or nivolumab and ipilimumab.

Inclusion Criteria

• Age from 12 months to 25 years
• Patient with a cancer that has come back (relapsed) or does not respond to treatment (refractory)
• All tumours can be considered except leukemia and diffuse intrinsic pontine glioma
• The tumour will be tested (part 1). It needs to to have an increased number of genetic changes for the patient to be considered for part 2
• Multiple other inclusion and exclusion criteria could apply and will be reviewed by your treating team

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Study Description

A clinical trial to look at how safe and tolerable the drug RO7428731 is at different doses, how the body processes it, and if there are any early signs of treatment efficacy of RO7428731 in patients with glioblastoma that has the marker EGFRvIII

Via: Clinical Trial – Glioblastoma – Safety, Tolerability, Pharm... (roche.com)

Inclusion Criteria

• Diagnosis of glioblastoma with a tumour expression called EGFRvIII
• Must have completed standard of care therapy prior to joining this study
• Must be up and about at least 70% of their waking hours
• Adequate organ functions prior to start of study treatment
• Willingness to abide by contraceptive measures for the duration of the study.

Other inclusion and exclusion criteria may apply and will be discussed with you by the study team

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Study Description

This study is to investigate how effective and safe the use of SPEAR™ T cells is in patients with Synovial Sarcoma or Myxoid/Round Cell Liposarcoma.

Inclusion Criteria

• Age ≥16 (10 years at selected sites) and <=75 years
• Diagnosis of advanced synovial sarcoma or myxoid liposarcoma / myxoid round cell liposarcoma with the appropriate genetic marker
• Measurable disease
• Adequate performance status (patient's level of functioning) 

Note: other protocol defined Inclusion criteria may apply and will be discussed with you by the study team.

Publications

A kinase-cGAS cascade to synthesize a therapeutic STING activator - PubMed (nih.gov)

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Study Description

The purpose of this study is to test the safety of an investigational drug called CFI-400945 alone and in combination with azacitidine.

Inclusion Criteria

• Patients must be >18 years of age
• Patients must have a qualifying diagnosis of Acute Myeloid Leukemia (AML), Myelodysplastic Syndromes (MDS), Chronic Myelomonocytic Leukemia (CMML) that has come back or not responded to other treatment
• Have acceptable laboratory screening results within certain limits
• Be able to carry out light daily work with little/no restriction

Other inclusion and exclusion criteria may apply and will be discussed with you by the study team

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Study Description

This trial will evaluate safety and efficacy of human engineered T-cell therapies, in participants with advanced tumours.

Inclusion Criteria

• Participant must be greater than or equal to 10 years of age on the day of signing informed consent.
• Participant has a diagnosis of synovial sarcoma (SS) or myxoid/round cell liposarcoma (MRCLS)
• Participant should be up and about 60% of their waking hours with minimal to no restrictions 
• Participant must meet the lab and organ function requirements prior to starting study

Other inclusion and exclusion criteria may apply and will be discussed with you by the study team