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Information is also accessible through the patient and families tab. Family friendly summaries are created and reviewed by our advocacy partners. The information is updated to the best of our knowledge but might not reflect the latest information. Note that most studies are only available at a limited number of sites, please click on ‘further information’ for details. Studies, particularly early phase trials, may also temporarily close to enrolment or not have slots available for all treatment groups. In all cases, study teams at individual C17 centres will have the most up-to-date information.

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NETTER-P - A Multicenter Open-label Study to Evaluate Safety and Dosimetry of Lutathera in Adolescent Patients With Somatostatin Receptor Positive Gastroenteropancreatic Neuroendocrine (GEP-NET) Tumors, Pheochromocytoma and Paragangliomas (PPGL)

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NETTER-P - A Multicenter Open-label Study to Evaluate Safety and Dosimetry of Lutathera in Adolescent Patients With Somatostatin Receptor Positive Gastroenteropancreatic Neuroendocrine (GEP-NET) Tumors, Pheochromocytoma and Paragangliomas (PPGL)

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DiagnosisGastroenteropancreatic Neuroendocrine Tumors, Pheochromocytoma, ParagangliomaStudy StatusOpen
PhaseII
Age12 to 17 Years OldRandomisationNO
Line of treatmentDisease relapse or progression
Routes of Treatment AdministrationDrug: Lutetium [177Lu] oxodotreotide/dotatate (Other Name: Lutathera) Radiopharmaceutical solution for infusion (7.4 GBq of Lutathera per 30 ml vial)
Last Posted Update2024-06-21
ClinicalTrials.gov #NCT04711135
International Sponsor
Advanced Accelerator Applications
Principal Investigators for Canadian Sites
CHU de Québec – Université Laval – Dr François-Alexandre Buteau
Centres
Medical contact
Raoul Santiago
 
Social worker/patient navigator contact
Isabelle Audet
 
Clinical research contact
Barbara Desbiens
 

 

 

 

Study Description

 

This is a phase 2 study designed to evaluate the safety of a drug called Lutathera in patients 12 to <18 years old with GEP-NET and PPGL disease. For patients on the study, this drug will be infused 4 times at 8-week intervals. After the infusions are complete, a follow-up period will take place after the last dose for each patient who received at least one dose of Lutathera.

Inclusion Criteria
  • Patients must have a diagnosis of GEP-NET or PPGL that has gotten worse or can not be operated on
  • Patients must be between 12 to <18 years old at the time of enrollment
  • Patients must be up and about for over half of their waking hours
  • Patients and their families (as applicable) must agree to sign the written informed consent forms outlined by the study team

Other inclusion and exclusion criteria may apply and will be discussed with you by the study team.